DMAE: Extending the Lifespan and Mental Capacity of Mice and Men

Posted on Apr 16, 2015

EZ Diet Note:  Good news, you can now extend the lifespan of rodents around your home, plus make them even smarter. : ) The implication is the DMAE mice research may also apply to humans. I’ve been taking DMAE for years because it’s one of Dr. Perricone’s top 10 supplements.

Here’s what Dr. Perricone says about DMAE:

DMAE is a naturally occurring nutritional substance with powerful anti-inflammatory properties; it is found in fish including wild Alaskan salmon, anchovies and sardines. DMAE is important in the production of neurotransmitters, which are essential in the communication from one nerve to another and between nerves and muscles. Taking DMAE as a supplement will not only improve your cognitive function by improving memory and problem-solving ability, it will help increase skin firmness and muscle tone—important for anyone on a weight loss or antiaging program.

Swanson – 130 mg 100 Caps $5.99 – 90 day supply

DMAE – Dimethylaminoethanol extends lifespan and improves learning in rodents

By AgeVivo, as seen at

The lifespan extending effect of dimethylaminol has been confirmed in multiple rodent experiments. The lifespan extending effect is higher when lower doses of the drug are used.

Effect of dimethylaminoethanol on rodent lifespan

DMEA improves memory

Proper dosing of DMEA

Effect of dimethylaminoethanol on rodent lifespan

R. Hochschild gave 57 old male mice dimethylaminoethanol (DMEA) in the drinking water from the age of 21 months. The mean lifespan of the mice was extended by 49.5%. The mice received 28.6 mg DMEA per liter drinking water. This is a dosage of 7 mg/kg body weight. The maximum survival time of the mice was increased by 36.3%. The equivalent human dose of the drug is 30 mg DMEA.

R. Hochschild published three papers in which the lifespan of mice were increased with the use of DMEA. In the second and third experiment the lifespan extension effect was 27.3% and 5.9%. But in these experiments higher doses of DMEA were used. Higher doses are less effective for extending lifespan in mice than lower doses. In the second experiment a dose of 20 mg/kg was used and in the third experiment a dose of 32.8 mg/kg was used. Denham Harman published a fourth experiment, and K. Nandy a fifth.

DMEA improves memory

When rodents get DMAE they score better on the maze test, this proves that DMEA improves memory. Autopsies show that the nervous systems of supplemented rats resemble those of young rats. DMEA is used as a nootropic and a dietary supplement. DMAE is converted into acetylcholine and maintains acetylcholine levels in older people at a more youthful level. Every time a nerve impulse is transmitted from one neuron to the next, a molecule of acetylcholine is used. There is a constant need for new acetylcholine synthesis. The levels of acetylcholine surrounding the nerves drops with age and the nerves begin to deteriorate as a result.

Proper dosing of DMEA

For the supplement to be effective proper dosing is important. The correct extrapolation of an animal dose to a human dose is performed through normalization to body surface area (BSA). A correction factor (Km) is determined by dividing the animals body weight by its BSA. The ratio of the animal Km value to the human’s Km value is than used for proper dose translation. The correction factor (Km) for a mice is 3 and for a human 37. The ratio of the animal to the human correction factor multiplied by the animal dose gives the human dose. The human dose is 0.57 mg/kg. This dose is multiplied by the body weight to know the amount to be taken. A person of 70 kg needs to take about 40 mg DMEA.


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